Chapters Transcript Video Phase 2 PROSPECT Study Presented by Lakshmi Nayak, MD. Lakshmi Nayak, MD presented results from a phase 2 PROSPECT study focused on tirabrutinib and it's effect on patients with relapsed or refractory primary central nervous system lymphoma. Primary CMS lymphoma is a rare and aggressive type of non-Hodgkin's lymphoma with limited treatment options in the relaps and refractory setting. There are no FDA approvals uh in this indication. Bruton's yazine kinase or BTK is a regulator of the B cell receptor signaling pathway, which is active in primary CNS. Lymphoma terabrutinib is an oral agent and the 2nd generation BTK inhibitor, which is highly selective and potent. We conducted the Prospect trial, which is a phase 2 multicenter open label study of terabruinib in relapse and refractory primary sus lymphoma. In the United States, in 48 patients, the objective response rate was 67%, and the complete response rate was 44%. Remarkably, we noted that the duration of response was quite long, with the median duration of response at 9.3 months. The drug was well tolerated with a manageable side effect profile, not different from expected. side effects from BTK inhibitors. These results are extremely encouraging and demonstrate that terrabutinib can be a feasible and effective option for patients with relaps and refractory primary CMS lymphoma. The hope is that the next steps include additional larger studies, including a randomized study, and eventual approval of Trutinib for relapse and refractory primary CNS lymphoma, so that this can be made available. for patients. We're also continuing research into using tabbutinib in the frontline setting in combination with chemotherapy, with the goal of achieving long term responses and with progress eventual cure. Published June 11, 2025 Created by Related Presenters Lakshmi Nayak, MD Neuro-oncology View full profile